Halogenated Nucleosides
2-(Trifluoromethyl)adenosine
Quick view. An adenosine nucleoside bearing a trifluoromethyl substituent at purine C2. CAS 4627-40-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2-(Trifluoromethyl)adenosine is classified as 2-trifluoromethyl adenosine nucleoside (Formula C11H12F3N5O4; molecular weight 335.24 g/mol).
2-(Trifluoromethyl)adenosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2-(Trifluoromethyl)adenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2-Trifluoromethyladenosine
- 4627-40-1
- XZAXKLMYAMKNFC-UUOKFMHZSA-N
Physicochemical data
| PubChem CID | 14430355 |
|---|---|
| IUPAC name | (2R,3R,4S,5R)-2-[6-amino-2-(trifluoromethyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol |
| InChIKey | XZAXKLMYAMKNFC-UUOKFMHZSA-N |
| InChI | InChI=1S/C11H12F3N5O4/c12-11(13,14)10-17-7(15)4-8(18-10)19(2-16-4)9-6(22)5(21)3(1-20)23-9/h2-3,5-6,9,20-22H,1H2,(H2,15,17,18)/t3-,5-,6-,9-/m1/s1 |
| SMILES | C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)C(F)(F)F)N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2-(Trifluoromethyl)adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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