2'-FANA Nucleosides
3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine
Quick view. A beta-D-arabino uridine derivative bearing 2'-fluoro substitution and 3',5'-bis-O-benzoyl protection, CAS 128496-10-6. CAS 128496-10-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine is classified as 2'-fana nucleosides (Formula C23H19FN2O7; molecular weight 454.40).
3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- CAS 128496-10-6
Physicochemical data
| Configuration | beta-D-arabino; 2'-fluoro |
|---|---|
| Protecting groups | 3',5'-bis-O-benzoyl |
| PubChem CID | 13963649 |
| InChI | InChI=1S/C23H19FN2O7/c24-18-19(33-22(29)15-9-5-2-6-10-15)16(13-31-21(28)14-7-3-1-4-8-14)32-20(18)26-12-11-17(27)25-23(26)30/h1-12,16,18-20H,13H2,(H,25,27,30)/t16-,18+,19-,20-/m1/s1 |
| InChIKey | UDRPYXIYNYCGKE-GSEOLPGOSA-N |
| SMILES | C1=CC=C(C=C1)C(=O)OC[C@@H]2[C@H]([C@@H]([C@@H](O2)N3C=CC(=O)NC3=O)F)OC(=O)C4=CC=CC=C4 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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