Modified Nucleosides
3'-O-(2-Methoxyethyl)-5-methylcytidine
Quick view. 5-Methylcytidine derivative bearing a 2-methoxyethyl ether at the 3' oxygen. CAS 2243311-50-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-(2-Methoxyethyl)-5-methylcytidine is classified as modified nucleosides (Formula C13H21N3O6; molecular weight 315.33 g/mol).
3'-O-(2-Methoxyethyl)-5-methylcytidine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-(2-Methoxyethyl)-5-methylcytidine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Useful catalog search terms
- 2243311-50-2
Physicochemical data
| Nucleoside | 5-Methylcytidine |
|---|---|
| Modification | 3'-O-(2-methoxyethyl) |
| InChIKey | MDRBPUHWFPPIRG-DNRKLUKYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(2-Methoxyethyl)-5-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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