Modified Nucleosides
3'-O-(2-Methoxyethyl)adenosine
Quick view. An adenosine nucleoside bearing a 3'-O-(2-methoxyethyl) substituent. CAS 303197-30-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-(2-Methoxyethyl)adenosine is classified as 3'-o-substituted adenosine nucleoside (Formula C13H19N5O5; molecular weight 325.32 g/mol).
3'-O-(2-Methoxyethyl)adenosine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-(2-Methoxyethyl)adenosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Useful catalog search terms
- 303197-30-0
- RHVMAYVXDAXYHR-QYVSTXNMSA-N
Physicochemical data
| PubChem CID | 18719643 |
|---|---|
| IUPAC name | (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-(2-methoxyethoxy)oxolan-3-ol |
| InChIKey | RHVMAYVXDAXYHR-QYVSTXNMSA-N |
| InChI | InChI=1S/C13H19N5O5/c1-21-2-3-22-10-7(4-19)23-13(9(10)20)18-6-17-8-11(14)15-5-16-12(8)18/h5-7,9-10,13,19-20H,2-4H2,1H3,(H2,14,15,16)/t7-,9-,10-,13-/m1/s1 |
| SMILES | COCCO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=CN=C32)N)CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(2-Methoxyethyl)adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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