Halogenated Nucleosides
5-Difluoromethyluridine
Quick view. 5-Difluoromethyluridine is a 5-substituted uridine nucleoside with CAS 110483-84-6. CAS 110483-84-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Product profile
5-Difluoromethyluridine is classified as halogenated nucleosides (Formula C10H12F2N2O6; molecular weight 294.21).
5-Difluoromethyluridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-Difluoromethyluridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- TNU0305
Useful catalog search terms
- CAS 110483-84-6
- 5-difluoromethyl uridine
Physicochemical data
| SMILES | C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(F)F |
|---|---|
| Nucleoside class | Uridine |
| Structural feature | 5-difluoromethyl substitution |
| PubChem CID | 54343230 |
| InChIKey | UALMIHJPIBPRGR-MWKIOEHESA-N |
| InChI | InChI=1S/C10H12F2N2O6/c11-7(12)3-1-14(10(19)13-8(3)18)9-6(17)5(16)4(2-15)20-9/h1,4-7,9,15-17H,2H2,(H,13,18,19)/t4-,5-,6-,9-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Difluoromethyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Trifluridine
Halogenated Nucleosides · CAS: 70-00-8
OR-HN-00026-Chloropurine 2'-deoxyriboside
Halogenated Nucleosides · CAS: 4594-45-0
OR-HN-00038-Chloro-2'-deoxyadenosine
Halogenated Nucleosides · CAS: 85562-55-6
OR-HN-00042'-Chloro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10212-19-8
OR-HN-00055-Bromo-2'-deoxycytidine
Halogenated Nucleosides · CAS: 1022-79-3
OR-HN-01535-Fluoro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10356-76-0
Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.