Modified Nucleosides
5-Hydroxy-2'-O-methyluridine
Quick view. Uridine derivative bearing a hydroxyl group at uracil C5 and a methyl group on the ribose 2'-oxygen, with free 3'- and 5'-hydroxyls. CAS 2030403-78-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Hydroxy-2'-O-methyluridine is classified as modified nucleosides (Formula C10H14N2O7; molecular weight 274.23 g/mol).
5-Hydroxy-2'-O-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-Hydroxy-2'-O-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 2030403-78-0
Physicochemical data
| Nucleobase modification | Uracil C5 hydroxyl |
|---|---|
| Sugar modification | 2'-O-methyl beta-D-ribofuranose |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
| InChIKey | XSRHWUSRVLRIKN-JXOAFFINSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-Hydroxy-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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