Halogenated Nucleosides
2',3'-Dideoxy-5-iodocytidine
Quick view. 2',3'-Dideoxy-5-iodocytidine is a dideoxycytidine nucleoside bearing iodine at pyrimidine C5, with CAS 114748-57-1. CAS 114748-57-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3'-Dideoxy-5-iodocytidine is classified as 5-iodo-2',3'-dideoxycytidine nucleoside (Formula C9H12IN3O3; molecular weight 337.11).
2',3'-Dideoxy-5-iodocytidine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 2',3'-Dideoxy-5-iodocytidine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 5-Iodo-2',3'-dideoxycytidine
- Cytidine, 2',3'-dideoxy-5-iodo-
- PubChem CID 14630104
Useful catalog search terms
- CAS 114748-57-1
Physicochemical data
| IUPAC name | 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one |
|---|---|
| InChI | InChI=1S/C9H12IN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h3,5,7,14H,1-2,4H2,(H2,11,12,15)/t5-,7+/m0/s1 |
| InChIKey | AMWJPSDPTPKJGN-CAHLUQPWSA-N |
| SMILES | C1C[C@@H](O[C@@H]1CO)N2C=C(C(=NC2=O)N)I |
| Structural feature | Pyrimidine C5 iodine with 2',3'-dideoxy sugar |
| PubChem CID | 14630104 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',3'-Dideoxy-5-iodocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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