Other Modified Nucleosides
5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG
Quick view. A guanine ribonucleoside analog bearing a 3'-O-methyl group, a free 2'-hydroxyl group and an E-vinyl phosphonate dimethyl ester at the 5' side. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG is classified as other modified nucleosides (Formula C14H20N5O7P; molecular weight 401.32).
5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For 5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Physicochemical data
| Nucleobase | Guanine |
|---|---|
| Sugar modification | 3'-O-methyl with free 2'-hydroxyl |
| 5' modification | E-vinyl phosphonate dimethyl ester |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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