2'-O-Me Nucleosides
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methylinosine
Quick view. A 5'-O-DMTr-protected 2'-O-methyl inosine derivative, CAS 128219-84-1. CAS 128219-84-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methylinosine is classified as 2'-o-me nucleosides (Formula C32H32N4O7; molecular weight 584.60).
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methylinosine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methylinosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-2'-O-methylinosine
- 5'-O-Dimethoxytrityl-2'-O-methylinosine
Useful catalog search terms
- CAS 128219-84-1
Physicochemical data
| Protecting groups | 5'-O-DMTr; 2'-O-methyl |
|---|---|
| 3' position | Free hydroxyl |
| PubChem CID | 136240754 |
| InChI | InChI=1S/C32H32N4O7/c1-39-23-13-9-21(10-14-23)32(20-7-5-4-6-8-20,22-11-15-24(40-2)16-12-22)42-17-25-27(37)28(41-3)31(43-25)36-19-35-26-29(36)33-18-34-30(26)38/h4-16,18-19,25,27-28,31,37H,17H2,1-3H3,(H,33,34,38)/t25-,27-,28-,31-/m1/s1 |
| InChIKey | KXFBGUCGEWPHRA-QWOIFIOOSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methylinosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.