Intermediates
5-(Trifluoromethyl)uracil-1-ylacetic acid
Quick view. A 5-(trifluoromethyl)uracil derivative bearing an N1-linked acetic acid group, CAS 1434143-40-4. CAS 1434143-40-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-(Trifluoromethyl)uracil-1-ylacetic acid is classified as intermediates (Formula C7H5F3N2O4; molecular weight 238.12).
5-(Trifluoromethyl)uracil-1-ylacetic acid — A carboxylic-acid-functionalized 5-(trifluoromethyl)uracil intermediate for research use in heterocycle and nucleobase-derivative synthesis.
For 5-(Trifluoromethyl)uracil-1-ylacetic acid, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5-Trifluoromethyl-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidineacetic acid
- 1(2H)-Pyrimidineacetic acid, 3,4-dihydro-2,4-dioxo-5-(trifluoromethyl)-
- TNU1055
- GL101694
Useful catalog search terms
- 5-Trifluoromethyluracil-1-yl acetic acid
- 1434143-40-4
Physicochemical data
| Heterocycle | Uracil |
|---|---|
| Ring substitution | C5 trifluoromethyl |
| N1 substituent | Acetic acid |
| Product form | Free carboxylic acid |
| PubChem CID | 54344909 |
| InChI | InChI=1S/C7H5F3N2O4/c8-7(9,10)3-1-12(2-4(13)14)6(16)11-5(3)15/h1H,2H2,(H,13,14)(H,11,15,16) |
| InChIKey | UBQARAVQYYEXIN-UHFFFAOYSA-N |
| SMILES | C1=C(C(=O)NC(=O)N1CC(=O)O)C(F)(F)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-(Trifluoromethyl)uracil-1-ylacetic acid or its named chemical feature. Broader product-family guidance is maintained on the category page.
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