Halogenated Nucleosides
2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-5-fluorouridine
Quick view. Protected uridine nucleoside bearing 2'-beta-C-methyl, nucleobase 5-fluoro, and 2',3',5'-tri-O-benzoyl substituents. CAS 2072145-49-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-5-fluorouridine is classified as halogenated nucleosides (Formula C31H25FN2O9; molecular weight 588.54 g/mol).
2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-5-fluorouridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-5-fluorouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2',3',5'-Tri-O-benzoyl-2'-C-methyl-5-fluorouridine
Useful catalog search terms
- 2072145-49-2
Physicochemical data
| Sugar substitution | 2'-beta-C-methyl |
|---|---|
| Nucleobase substitution | 5-fluoro |
| Protection pattern | 2',3',5'-tri-O-benzoyl |
| InChIKey | DBNWXXHQEQCDIA-KTWNKCLUSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-5-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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