2'-F-ANA Phosphoramidites
N2-Isobutyryl-5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinoguanosine-3'-CE phosphoramidite
Quick view. A protected 2'-F-ANA guanosine building block bearing N2-isobutyryl and 5'-O-DMTr groups with a 3'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 1404463-20-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Isobutyryl-5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinoguanosine-3'-CE phosphoramidite is classified as 2'-f-ana phosphoramidites (Formula C44H53FN7O8P; molecular weight 857.92).
N2-Isobutyryl-5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinoguanosine-3'-CE phosphoramidite — Identity-defined 2'-F-ANA-dG(iBu) phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For N2-Isobutyryl-5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinoguanosine-3'-CE phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-ANA-dG(iBu) phosphoramidite
- 2'-F-2'-ara-N2-iBu-dG phosphoramidite
- ANA 2'-F G(iBu) amidite
Useful catalog search terms
- CAS 1404463-20-2
Physicochemical data
| Nucleoside | 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine |
|---|---|
| Base protection | N2-Isobutyryl |
| 5' protection | DMTr |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| PubChem CID | 137213540 |
| InChI | InChI=1S/C44H53FN7O8P/c1-27(2)40(53)49-43-48-39-37(41(54)50-43)47-26-51(39)42-36(45)38(60-61(58-24-12-23-46)52(28(3)4)29(5)6)35(59-42)25-57-44(30-13-10-9-11-14-30,31-15-19-33(55-7)20-16-31)32-17-21-34(56-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H2,48,49,50,53,54)/t35-,36+,38-,42-,61?/m1/s1 |
| InChIKey | KJFUMXZZVYMQEU-SJIRJWTBSA-N |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N2-Isobutyryl-5'-O-DMTr-2'-deoxy-2'-fluoro-beta-D-arabinoguanosine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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