Base-protected Nucleosides
2'-O-Me-rC(Bz)
Quick view. N4-Benzoyl-2'-O-methylcytidine with free 3'- and 5'-hydroxyl groups. CAS 52571-45-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Me-rC(Bz) is classified as base-protected nucleosides (Formula C17H19N3O6; molecular weight 361.36).
2'-O-Me-rC(Bz) supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Me-rC(Bz), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N4-Benzoyl-2'-O-methylcytidine
- N4-Bz-2'-O-Me-rC
Useful catalog search terms
- CAS 52571-45-6
Physicochemical data
| InChIKey | LIZIIHWLABYQKD-XKVFNRALSA-N |
|---|---|
| Nucleoside | Cytidine |
| Base protection | N4-benzoyl |
| Sugar modification | 2'-O-methyl |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
| InChI | InChI=1S/C17H19N3O6/c1-25-14-13(22)11(9-21)26-16(14)20-8-7-12(19-17(20)24)18-15(23)10-5-3-2-4-6-10/h2-8,11,13-14,16,21-22H,9H2,1H3,(H,18,19,23,24)/t11-,13-,14-,16-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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