2'-O-MOE Nucleosides
2'-O-(2-Methoxyethyl)guanosine
Quick view. 2'-O-(2-Methoxyethyl)guanosine is a 2'-O-MOE-modified nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 473278-54-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Product profile
2'-O-(2-Methoxyethyl)guanosine is classified as 2'-o-moe nucleoside (Formula C13H19N5O6; molecular weight 341.32).
2'-O-(2-Methoxyethyl)guanosine — A 2'-O-(2-methoxyethyl)-modified guanosine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-O-(2-Methoxyethyl)guanosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-rG
- 2'-MOE-rG
- Guanosine, 2'-O-(2-methoxyethyl)-
Useful catalog search terms
- CAS 473278-54-5
Physicochemical data
| PubChem CID | 135544588 |
|---|---|
| InChIKey | DLLBJSLIKOKFHE-WOUKDFQISA-N |
| Modification | 2-methoxyethyl ether at the ribose 2'-oxygen |
| InChI | InChI=1S/C13H19N5O6/c1-22-2-3-23-9-8(20)6(4-19)24-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h5-6,8-9,12,19-20H,2-4H2,1H3,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s1 |
| SMILES | COCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(O)nc(=N)[nH]c21 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-(2-Methoxyethyl)guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-(2-Methoxyethyl)inosine
2'-O-MOE Nucleosides · CAS: 545374-76-3
OR-MN-01672'-O-(2-Methoxyethyl)-5-methylcytidine
2'-O-MOE Nucleosides · CAS: 244105-55-3
OR-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
OR-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
OR-MN-01712'-O-(2-Methoxyethyl)uridine
2'-O-MOE Nucleosides · CAS: 223777-15-9
OR-MN-01742'-O-(2-Methoxyethyl)-5-methyluridine
2'-O-MOE Nucleosides · CAS: 163759-49-7
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.