Succinates
DMTr-2'-OMe-U-3'-Succinate, TEA Salt
Quick view. DMTr-2'-OMe-U-3'-Succinate, TEA Salt is a protected 2'-O-methyluridine derivative bearing 5'-O-DMTr and a 3'-O-succinate group, with triethylamine explicitly represented. The reviewed identity corresponds to PubChem CID 138376012. CAS 1792211-00-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-OMe-U-3'-Succinate, TEA Salt is classified as protected 2'-o-methyluridine 3'-o-succinate triethylamine salt (Formula C41H51N3O11; molecular weight 761.90).
DMTr-2'-OMe-U-3'-Succinate, TEA Salt supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For DMTr-2'-OMe-U-3'-Succinate, TEA Salt, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-methyluridine-3'-succinate, triethylamine salt
Useful catalog search terms
- CAS 1792211-00-7
- Succinates
Physicochemical data
| PubChem CID | 138376012 |
|---|---|
| InChIKey | NSOHGEALAZXRED-JLUFNGKWSA-N |
| Structural features | 5'-O-DMTr; 2'-O-methyl; uracil nucleobase; 3'-O-succinate; triethylamine component |
| InChI | InChI=1S/C35H36N2O11.C6H15N/c1-43-25-13-9-23(10-14-25)35(22-7-5-4-6-8-22,24-11-15-26(44-2)16-12-24)46-21-27-31(48-30(41)18-17-29(39)40)32(45-3)33(47-27)37-20-19-28(38)36-34(37)42;1-4-7(5-2)6-3/h4-16,19-20,27,31-33H,17-18,21H2,1-3H3,(H,39,40)(H,36,38,42);4-6H2,1-3H3/t27-,31-,32-,33-;/m1./s1 |
| SMILES | CCN(CC)CC.CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OC(=O)CCC(=O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-OMe-U-3'-Succinate, TEA Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Succinates product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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