Halogenated Nucleosides
3',5'-Di-O-acetyl-5-bromo-2'-O-methyluridine
Quick view. 3',5'-Di-O-acetyl-5-bromo-2'-O-methyluridine is a protected halogenated uridine derivative with CAS 1188522-81-7. CAS 1188522-81-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Product profile
3',5'-Di-O-acetyl-5-bromo-2'-O-methyluridine is classified as protected halo- and 2'-o-methyl nucleoside (Formula C14H17BrN2O8; molecular weight 421.20).
3',5'-Di-O-acetyl-5-bromo-2'-O-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 3',5'-Di-O-acetyl-5-bromo-2'-O-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5-Bromo-2'-O-methyluridine 3',5'-diacetate
Useful catalog search terms
- CAS 1188522-81-7
Physicochemical data
| InChIKey | SRIIZANGRRSQIV-PRULPYPASA-N |
|---|---|
| Structural feature | 3',5'-O-acetyl protection with 5-bromo and 2'-O-methyl substitution |
| PubChem CID | 71501016 |
| InChI | InChI=1S/C14H17BrN2O8/c1-6(18)23-5-9-10(24-7(2)19)11(22-3)13(25-9)17-4-8(15)12(20)16-14(17)21/h4,9-11,13H,5H2,1-3H3,(H,16,20,21)/t9-,10-,11-,13-/m1/s1 |
| SMILES | CC(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)Br)OC)OC(=O)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3',5'-Di-O-acetyl-5-bromo-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Trifluridine
Halogenated Nucleosides · CAS: 70-00-8
OR-HN-00026-Chloropurine 2'-deoxyriboside
Halogenated Nucleosides · CAS: 4594-45-0
OR-HN-00038-Chloro-2'-deoxyadenosine
Halogenated Nucleosides · CAS: 85562-55-6
OR-HN-00042'-Chloro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10212-19-8
OR-HN-00055-Bromo-2'-deoxycytidine
Halogenated Nucleosides · CAS: 1022-79-3
OR-HN-01535-Fluoro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10356-76-0
Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.