Other Phosphoramidites
3'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluorouridine-2'-CED-phosphoramidite
Quick view. A 5'-O-DMTr-protected 3'-deoxy-3'-fluorouridine 2'-CED phosphoramidite, CAS 129015-63-0. CAS 129015-63-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluorouridine-2'-CED-phosphoramidite is classified as other phosphoramidites (Formula C39H46FN4O8P; molecular weight 748.79 g/mol).
3'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluorouridine-2'-CED-phosphoramidite is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluorouridine-2'-CED-phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- CAS 129015-63-0
Physicochemical data
| Modification | 3'-deoxy-3'-fluoro |
|---|---|
| 5' protection | DMTr |
| Phosphoramidite position | 2'-CED |
| Calculated molecular weight | 748.79 g/mol |
| Covalent SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H]2F)(c2ccccc2)c2ccc(OC)cc2)cc1 |
| Canonical covalent SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H]2F)(c2ccccc2)c2ccc(OC)cc2)cc1 |
| Covalent InChI | InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-35(40)33(51-37(36)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/m1/s1 |
| Covalent InChIKey | YEGXPHIEMDBCGN-DJTPZYMWSA-N |
| PubChem CID | 102450104 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluorouridine-2'-CED-phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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