Reverse Phosphoramidites
3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite
Quick view. A 2'-O-MOE 5-methyluridine reverse phosphoramidite with 3'-O-DMTr protection and a 5'-O cyanoethyl diisopropyl phosphoramidite group. CAS 1345715-43-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite is classified as reverse phosphoramidites (Formula C43H55N4O10P; molecular weight 818.90 g/mol).
3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite — Reverse-direction oligonucleotide synthesis
For 3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- Rev 2'-O-MOE-5MeU-5'-amidite
- 3'-O-DMTr-2'-O-MOE-5MeU-5'-CE-Phosphoramidite
Useful catalog search terms
- 1345715-43-6
- YXJWAPDGJHYLNH-KZQAAKLLSA-N
Physicochemical data
| PubChem CID | 167312644 |
|---|---|
| IUPAC name | 3-[[(2R,3R,4R,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile |
| InChIKey | YXJWAPDGJHYLNH-KZQAAKLLSA-N |
| InChI | InChI=1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(54-24-12-23-44)55-28-37-38(39(53-26-25-50-6)41(56-37)46-27-31(5)40(48)45-42(46)49)57-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,27,29-30,37-39,41H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38-,39-,41-,58?/m1/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(N(C(C)C)C(C)C)OCCC#N)OC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OCCOC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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