2'-O-Me Nucleosides
5'-Azido-5'-deoxy-2'-O-methyluridine
Quick view. A 2'-O-methyluridine derivative bearing a 5'-azido-5'-deoxy substitution, CAS 194034-68-9. CAS 194034-68-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Azido-5'-deoxy-2'-O-methyluridine is classified as 2'-o-me nucleosides (Formula C10H13N5O5; molecular weight 283.24).
5'-Azido-5'-deoxy-2'-O-methyluridine is useful as a bioorthogonal handle for post-synthetic conjugation to fluorophores, affinity tags, surfaces, peptides or other functional payloads.
For 5'-Azido-5'-deoxy-2'-O-methyluridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- Uridine, 5'-azido-5'-deoxy-2'-O-methyl-
- MFCD30718530
- GL102026
- CB83203969
Useful catalog search terms
- CAS 194034-68-9
- C10H13N5O5
- QQTLIVFPXXFWEK-ZOQUXTDFSA-N
Physicochemical data
| Nucleobase | Uracil |
|---|---|
| Sugar modification | 2'-O-Methyl |
| 5'-substitution | 5'-Azido-5'-deoxy |
| Free hydroxyl | 3'-OH |
| Stereochemistry | Four assigned ribofuranosyl stereocenters |
| InChI | InChI=1S/C10H13N5O5/c1-19-8-7(17)5(4-12-14-11)20-9(8)15-3-2-6(16)13-10(15)18/h2-3,5,7-9,17H,4H2,1H3,(H,13,16,18)/t5-,7-,8-,9-/m1/s1 |
| InChIKey | QQTLIVFPXXFWEK-ZOQUXTDFSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CN=[N+]=[N-])O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-Azido-5'-deoxy-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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