Halogenated Nucleosides
5-(Trifluoromethyl)uridine
Quick view. Uridine nucleoside bearing a trifluoromethyl substituent at the nucleobase C5 position. CAS 21618-67-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-(Trifluoromethyl)uridine is classified as halogenated nucleosides (Formula C10H11F3N2O6; molecular weight 312.20 g/mol).
5-(Trifluoromethyl)uridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-(Trifluoromethyl)uridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 5-Trifluoromethyluridine
- 21618-67-7
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Modification | 5-trifluoromethyl |
| Sugar form | Ribose |
| Protection state | Unprotected |
| InChIKey | UEJHQHNFRZXWRD-UAKXSSHOSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-(Trifluoromethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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