2'-O-Me Phosphoramidites
6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite
Quick view. 6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite is an N4-acetyl-protected 2'-O-methyl-5'-homo-cytidine building block for research-use oligonucleotide synthesis. CAS 2714382-70-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite is classified as protected 2'-o-methyl-5'-homo-cytidine phosphoramidite (Formula C43H54N5O9P; molecular weight 815.90).
6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite — N4-acetyl-protected 2'-O-methyl-5'-homo-cytidine phosphoramidite building block for research-use oligonucleotide synthesis.
For 6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 6'-O-DMT-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite
- 6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-2-cyanoethyl phosphoramidite
Useful catalog search terms
- 2714382-70-2
- PubChem 178421323
- C43H54N5O9P
- Synthgene PA229
- 2'-O-Me Phosphoramidites
Physicochemical data
| Base protection | N4-acetyl |
|---|---|
| Ribose modification | 2'-O-methyl and 5'-homo |
| Synthesis format | 6'-O-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | OKRVIGGVQOSGIC-PENKXTLKSA-N |
| InChI | InChI=1S/C43H54N5O9P/c1-29(2)48(30(3)4)58(55-27-12-25-44)57-39-37(56-41(40(39)53-8)47-26-23-38(45-31(5)49)46-42(47)50)24-28-54-43(32-13-10-9-11-14-32,33-15-19-35(51-6)20-16-33)34-17-21-36(52-7)22-18-34/h9-11,13-23,26,29-30,37,39-41H,12,24,27-28H2,1-8H3,(H,45,46,49,50)/t37-,39-,40-,41-,58?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OC)N2C=CC(=NC2=O)NC(=O)C)CCOC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC |
| PubChem CID | 178421323 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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