Cap Analogs
m7(3'-OMeG)(5')ppp(5')(2'-OMeG)pG ammonium salt
Quick view. A modified GGG trinucleotide Cap1 analog in ammonium-salt form for RNA-synthesis research. CAS 2089461-54-9 and the listed composition refer to the free-acid identity; ammonium stoichiometry is variable. CAS 2089461-54-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
m7(3'-OMeG)(5')ppp(5')(2'-OMeG)pG ammonium salt is classified as cap analogs.
m7(3'-OMeG)(5')ppp(5')(2'-OMeG)pG ammonium salt — Modified trinucleotide Cap1 analog for RNA capping and modification research.
For m7(3'-OMeG)(5')ppp(5')(2'-OMeG)pG ammonium salt, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- CAP GGG(3'OMe) m7(3'OMeG)(5')ppp(5')(2'OMeG)pG Ammonium Salt
- m7(3'OMeG)ppp(2'OMeG)pG ammonium salt
- CAP GGG(3'OMe)
- BRP-00638
Useful catalog search terms
- CAS 2089461-54-9
- m7(3'OMeG)ppp(2'OMeG)pG
Physicochemical data
| Related CAS | 2089461-54-9 (free acid) |
|---|---|
| Counterion form | Ammonium salt (xNH4; stoichiometry unspecified) |
| Nucleotide shorthand | m7(3'-OMeG)(5')ppp(5')(2'-OMeG)pG |
| Cap classification | Cap1 |
| Free-acid molecular formula | C33H45N15O25P4 |
| Formula basis | Free-acid form |
| Free-acid molecular weight | 1175.69 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe m7(3'-OMeG)(5')ppp(5')(2'-OMeG)pG ammonium salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-CA-0005CAP 6 m7G(LNA)(5')ppp(5')(2'OMeA)pG Triammonium Salt
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OR-CA-0006CAP 7 m7G(HNA)(5')ppp(5')(2'OMeA)pG Ammonium Salt
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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