OROGO PRODUCT DIRECTORY
Synthesis-Cycle Reagents Coupling Activators
Activators for phosphoramidite coupling cycles, including tetrazole- and imidazole-based reagents used in oligonucleotide synthesis. Confirm the exact identity, supplied form, specification, package and current availability on the product page or by inquiry.
Category guide
Coupling activators promote reaction of a phosphoramidite with the growing oligonucleotide chain in DNA, RNA and modified-monomer synthesis.
Match acidity, acetonitrile solubility, activation speed and concentration to the monomer set, synthesizer and target sequence.
Control water content and solution age, then compare full-length yield, deletion products and side reactions in a representative coupling study.
Product-family considerations
- Activator choice can improve difficult couplings and help balance conversion against acid-driven side reactions.
- Dissolution behavior and acidity profiles allow method developers to match the activator to the monomer set and synthesizer platform.
- Overly acidic or mismatched activators may increase detritylation-related side products, dimer formation or n+1 impurities.
- Concentration, water content, reagent age and amidite compatibility should be controlled in routine production methods.
Selection checklist
| Exact identity | Match the canonical name with a CAS number, structure, SMILES or drawing; confirm stereochemistry, protecting groups and salt form where applicable. |
|---|---|
| Specification | Define target purity, analytical method, water or residual-solvent concerns and application-specific acceptance limits. |
| Workflow fit | Share the reaction, enzyme, sequence, solvent system, support or analytical method used to evaluate compatibility. |
| Supply need | Provide initial quantity, expected future scale, packaging preference, timeline and documentation requirements. |
Product comparison
This snapshot compares up to eight products using published catalog fields only. Confirm the exact supplied form, pack size, specification and current availability by inquiry.
Swipe or scroll horizontally to compare all fields.
| Product name | OR catalog no. | CAS | Purity / specification | Supply status |
|---|---|---|---|---|
| 4,5-Dicyanoimidazole (DCI) | OR-CA-0035 | 1122-28-7 | Specification by inquiry | Inquiry only |
| 5-(Benzylthio)-1H-tetrazole (BTT) | OR-CA-0036 | 21871-47-6 | Specification by inquiry | Inquiry only |
| 5-(Ethylthio)-1H-tetrazole (ETT) | OR-CA-0037 | 89797-68-2 | Specification by inquiry | Inquiry only |
3 products
OR-CA-00354,5-Dicyanoimidazole (DCI)
Synthesis-Cycle Reagents / Coupling Activators
- CAS
- 1122-28-7
- Purity / form
- Specification by inquiry
- Availability
- Inquiry only — contact OROGO to confirm current availability
OR-CA-00365-(Benzylthio)-1H-tetrazole (BTT)
Synthesis-Cycle Reagents / Coupling Activators
- CAS
- 21871-47-6
- Purity / form
- Specification by inquiry
- Availability
- Inquiry only — contact OROGO to confirm current availability
OR-CA-00375-(Ethylthio)-1H-tetrazole (ETT)
Synthesis-Cycle Reagents / Coupling Activators
- CAS
- 89797-68-2
- Purity / form
- Specification by inquiry
- Availability
- Inquiry only — contact OROGO to confirm current availability
Category literature
Background literature for this product family; it does not establish an OROGO product specification, supplied form, availability or performance.
Frequently asked questions
What are typical uses for Coupling Activators?
Coupling activators promote reaction of a phosphoramidite with the growing oligonucleotide chain in DNA, RNA and modified-monomer synthesis.
What should be confirmed before ordering Coupling Activators?
Match acidity, acetonitrile solubility, activation speed and concentration to the monomer set, synthesizer and target sequence.
Are custom quantities or related analogs available?
OROGO reviews custom package sizes, catalog-adjacent analogs and research-use custom synthesis requests against the target structure, purity, scale and timeline.
Need a related form?
Search the complete catalog or send the target name, structure, quantity and specification for a catalog match or custom chemistry review.