2'-Fluoro Phosphoramidites
DMTr-(2'R)-2'-F-2'-Me-dU-3'-CE-Phosphoramidite
Quick view. A protected 2'-deoxy-2'-fluoro-2'-C-methyluridine phosphoramidite building block for research-use oligonucleotide synthesis. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-(2'R)-2'-F-2'-Me-dU-3'-CE-Phosphoramidite is classified as protected 2'-f/me uridine phosphoramidite (Formula C40H48FN4O8P; molecular weight 762.82).
DMTr-(2'R)-2'-F-2'-Me-dU-3'-CE-Phosphoramidite — The corresponding 2'-F/Me uridine phosphoramidite was synthesized and incorporated into oligonucleotides in a reported study.
For DMTr-(2'R)-2'-F-2'-Me-dU-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- DMT-(2'R)-2'-F-2'-Me-dU-3'-CE-Phosphoramidite
- 5'-O-DMTr-(2'R)-2'-fluoro-2'-C-methyl-dU-3'-CE phosphoramidite
Useful catalog search terms
- 2'-F/Me uridine phosphoramidite
Physicochemical data
| Nucleobase | Uracil |
|---|---|
| 5' protection | 4,4'-Dimethoxytrityl (DMTr) |
| Sugar modification | 2'-deoxy-2'-alpha-fluoro-2'-beta-C-methyl |
| 3'-function | 2-cyanoethyl N,N-diisopropyl phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-(2'R)-2'-F-2'-Me-dU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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Technology platforms
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