Other Phosphoramidites
3'-O-MOE-G(iBu)-2'-CED-phosphoramidite
Quick view. An N2-isobutyryl-protected guanosine phosphoramidite bearing 5'-O-DMTr, a 3'-O-(2-methoxyethyl) substituent, and a 2'-O-cyanoethyl phosphoramidite group. CAS 256224-06-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-MOE-G(iBu)-2'-CED-phosphoramidite is classified as protected modified guanosine phosphoramidite (Formula C47H60N7O10P; molecular weight 913.99).
3'-O-MOE-G(iBu)-2'-CED-phosphoramidite — Modified guanosine phosphoramidite building block for research-use oligonucleotide synthesis.
For 3'-O-MOE-G(iBu)-2'-CED-phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- DMTr-3'-O-MOE-rG(iBu)-2'-CE-Phosphoramidite
Useful catalog search terms
- 256224-06-3
Physicochemical data
| Base protection | N2-isobutyryl |
|---|---|
| 5' protection | DMTr |
| 3' substituent | 2-methoxyethyl |
| Phosphoramidite group | 2'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-MOE-G(iBu)-2'-CED-phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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