Modified Nucleotides
Im-3'-OMe-GMP
Quick view. A 3'-O-methylguanosine 5'-monophosphate phosphoroimidazolide. Formula and molecular weight refer to the free acid; CAS 1932688-83-9 is separately reported for a sodium-salt form. CAS 1005791-93-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
Im-3'-OMe-GMP is classified as modified nucleotides (Formula C14H18N7O7P; molecular weight 427.31).
TargetMol describes Im-3'-OMe-GMP as a monomeric material for nucleic acid synthesis.
For Im-3'-OMe-GMP, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- Guanosine, 3'-O-methyl-, 5'-(hydrogen P-1H-imidazol-1-ylphosphonate)
Useful catalog search terms
- 3'-O-methylguanosine 5'-monophosphate phosphoroimidazolide
- CAS 1005791-93-4
- CAS 1932688-83-9
Physicochemical data
| PubChem CID | 169221876 |
|---|---|
| Parent identity | 3'-O-methylguanosine 5'-monophosphate phosphoroimidazolide |
| Primary CAS | 1005791-93-4 (free acid) |
| Related salt CAS | 1932688-83-9 (sodium salt) |
| Salt boundary | Current media uses variable sodium notation; exact stoichiometry unspecified |
| InChIKey | LCOHHNQJGGQHSJ-QYVSTXNMSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe Im-3'-OMe-GMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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