2'-O-Propargyl Phosphoramidites
N2-Ac-DMT-2'-O-propargyl-G-CE-Phosphoramidite
Quick view. An N2-acetyl, 5'-O-DMTr-protected 2'-O-propargyl guanosine CE phosphoramidite for oligonucleotide synthesis research. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Ac-DMT-2'-O-propargyl-G-CE-Phosphoramidite is classified as 2'-o-propargyl phosphoramidites (Formula C45H52N7O9P; molecular weight 865.91).
N2-Ac-DMT-2'-O-propargyl-G-CE-Phosphoramidite — Protected N2-acetyl guanosine phosphoramidite building block for oligonucleotide synthesis research.
For N2-Ac-DMT-2'-O-propargyl-G-CE-Phosphoramidite, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- [N2-acetyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-guanosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite
- DMT-2'-O-propynyl-G(Ac)-CE-phosphoramidite
Physicochemical data
| Base protection | N2-acetyl guanosine |
|---|---|
| 5' protection | DMTr |
| Sugar modification | 2'-O-propargyl |
| 3' functionality | 2-cyanoethyl N,N-diisopropylphosphoramidite |
| Phosphorus configuration | Unspecified |
| Covalent InChIKey | HJFWRIKHRWBAKQ-GDLAVZMWSA-N |
| Covalent InChI | InChI=1S/C45H52N7O9P/c1-9-25-57-40-39(61-62(59-26-13-24-46)52(29(2)3)30(4)5)37(60-43(40)51-28-47-38-41(51)49-44(48-31(6)53)50-42(38)54)27-58-45(32-14-11-10-12-15-32,33-16-20-35(55-7)21-17-33)34-18-22-36(56-8)23-19-34/h1,10-12,14-23,28-30,37,39-40,43H,13,25-27H2,2-8H3,(H2,48,49,50,53,54)/t37-,39-,40-,43-,62?/m1/s1 |
| Covalent SMILES | C#CCO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1cnc2c(=O)nc(NC(C)=O)[nH]c21 |
| Canonical covalent SMILES | C#CCO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1cnc2c(=O)nc(NC(C)=O)[nH]c21 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe N2-Ac-DMT-2'-O-propargyl-G-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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