Modified Nucleosides
N2-Isobutyryl-3'-O-methylguanosine
Quick view. An N2-isobutyryl-protected 3'-O-methylguanosine building block for structure-specific modified-nucleoside and nucleotide synthesis research. CAS 160107-07-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Isobutyryl-3'-O-methylguanosine is classified as modified nucleosides (Formula C15H21N5O6; molecular weight 367.36).
N2-Isobutyryl-3'-O-methylguanosine — N2-isobutyryl-protected 3'-O-methylguanosine building block for structure-specific modified-nucleoside and nucleotide synthesis research.
For N2-Isobutyryl-3'-O-methylguanosine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- N2-iso-Butyroyl-3'-O-methylguanosine
Useful catalog search terms
- CAS 160107-07-3
- PubChem CID 145710473
Physicochemical data
| PubChem CID | 145710473 |
|---|---|
| InChIKey | WKXJLMCHKRMCEY-AKAIJSEGSA-N |
| IUPAC name | N-[9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)OC)O |
| Base protection | N2-isobutyryl |
| Sugar modification | 3'-O-methyl |
| InChI | InChI=1S/C15H21N5O6/c1-6(2)12(23)18-15-17-11-8(13(24)19-15)16-5-20(11)14-9(22)10(25-3)7(4-21)26-14/h5-7,9-10,14,21-22H,4H2,1-3H3,(H2,17,18,19,23,24)/t7-,9-,10-,14-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe N2-Isobutyryl-3'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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