2'-O-Me Nucleosides
DMTr-2'-O-Me-5-Me-C(Bz)
Quick view. DMTr-2'-O-Me-5-Me-C(Bz) is an N4-benzoyl- and 5'-O-DMTr-protected 2'-O-methyl-5-methylcytidine building block. The reviewed identity is CAS 741725-57-5. CAS 741725-57-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-O-Me-5-Me-C(Bz) is classified as protected 2'-o-methyl-5-methylcytidine (Formula C39H39N3O8; molecular weight 677.74 g/mol).
DMTr-2'-O-Me-5-Me-C(Bz) supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For DMTr-2'-O-Me-5-Me-C(Bz), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N4-Benzoyl-5'-O-DMTr-2'-O-methyl-5-methylcytidine
- N4-Bz-DMT-2'-OMe-5-Me-Cr
- 5'-O-DMT-2'-OMe-N4-Bz-5-Me-C
Useful catalog search terms
- CAS 741725-57-5
- 2'-O-Me Nucleosides
Physicochemical data
| InChIKey | BUUDDUQHVVDKLA-TUDCZORBSA-N |
|---|---|
| MDL number | MFCD01631037 |
| Storage temperature | -18 C (supplier-listed) |
| Structural features | N4-benzoyl; 5'-O-DMTr; 2'-O-methyl; 5-methylcytidine |
| PubChem CID | 68499363 |
| InChI | InChI=1S/C39H39N3O8/c1-25-23-42(38(45)41-35(25)40-36(44)26-11-7-5-8-12-26)37-34(48-4)33(43)32(50-37)24-49-39(27-13-9-6-10-14-27,28-15-19-30(46-2)20-16-28)29-17-21-31(47-3)22-18-29/h5-23,32-34,37,43H,24H2,1-4H3,(H,40,41,44,45)/t32-,33-,34-,37-/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(NC(=O)c4ccccc4)nc3=O)[C@H](OC)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-5-Me-C(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.