Halogenated Nucleosides
N6-benzoyl-3'-fluoro-2',3'-dideoxyadenosine
Quick view. An N6-benzoyl-protected adenosine derivative with a 3'-fluoro-2',3'-dideoxy sugar and a free 5'-hydroxyl, CAS 122712-71-4. CAS 122712-71-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N6-benzoyl-3'-fluoro-2',3'-dideoxyadenosine is classified as halogenated nucleosides (Formula C17H16FN5O3; molecular weight 357.34).
N6-benzoyl-3'-fluoro-2',3'-dideoxyadenosine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For N6-benzoyl-3'-fluoro-2',3'-dideoxyadenosine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- TNU1247
- orb1907757
- GL102595
Useful catalog search terms
- CAS 122712-71-4
Physicochemical data
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO)F |
|---|---|
| Base protection | N6-benzoyl |
| Sugar modification | 3'-fluoro-2',3'-dideoxy |
| Hydroxyl state | 5' hydroxyl unprotected |
| PubChem CID | 71352014 |
| InChIKey | RWKXHBQARYLBBO-YNEHKIRRSA-N |
| InChI | InChI=1S/C17H16FN5O3/c18-11-6-13(26-12(11)7-24)23-9-21-14-15(19-8-20-16(14)23)22-17(25)10-4-2-1-3-5-10/h1-5,8-9,11-13,24H,6-7H2,(H,19,20,22,25)/t11-,12+,13+/m0/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N6-benzoyl-3'-fluoro-2',3'-dideoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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