GalNAc
Peracetylated GalNAc succinimidyl pentanoate
Quick view. Peracetylated GalNAc succinimidyl pentanoate is a protected beta-D-GalNAc pentanoic-acid N-hydroxysuccinimide ester, identified by CAS 1953146-64-9. CAS 1953146-64-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
Peracetylated GalNAc succinimidyl pentanoate is classified as galnac (Formula C23H32N2O13; molecular weight 544.51).
Peracetylated GalNAc succinimidyl pentanoate can be used when comparing GalNAc ligand/linker architecture for liver-targeted oligonucleotide conjugation research.
For Peracetylated GalNAc succinimidyl pentanoate, in-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
Names and search terms
Confirmed or normalized name variants
- Peracetylated beta-D-GalNAc pentanoic acid NHS ester
Useful catalog search terms
- CAS 1953146-64-9
- OVRUOPINRDOPSA-UJGPHIHISA-N
Physicochemical data
| IUPAC name | (2,5-dioxopyrrolidin-1-yl) 5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoate |
|---|---|
| InChIKey | OVRUOPINRDOPSA-UJGPHIHISA-N |
| Chemical form | Peracetylated beta-D-GalNAc pentanoic-acid N-hydroxysuccinimide ester |
| InChI | InChI=1S/C23H32N2O13/c1-12(26)24-20-22(36-15(4)29)21(35-14(3)28)16(11-34-13(2)27)37-23(20)33-10-6-5-7-19(32)38-25-17(30)8-9-18(25)31/h16,20-23H,5-11H2,1-4H3,(H,24,26)/t16-,20-,21+,22-,23-/m1/s1 |
| SMILES | CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OCCCCC(=O)ON2C(=O)CCC2=O)COC(=O)C)OC(=O)C)OC(=O)C |
| Canonical SMILES | CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OCCCCC(=O)ON2C(=O)CCC2=O)COC(=O)C)OC(=O)C)OC(=O)C |
| PubChem CID | 156724416 |
| Structure representation | Peracetylated beta-D-GalNAc pentanoic-acid N-hydroxysuccinimide ester with five assigned sugar stereocentres |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- A defined GalNAc intermediate helps decouple ligand-linker optimization from sequence optimization.
Method limitations
- In-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
These points describe Peracetylated GalNAc succinimidyl pentanoate or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the GalNAc product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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