Intermediates
TCO-PEG6-acid
Quick view. TCO-PEG6-acid is a trans-cyclooctene PEG carboxylic-acid linker intermediate identified by CAS 2353409-97-7. CAS 2353409-97-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
TCO-PEG6-acid is classified as intermediates (Formula C24H43NO10; molecular weight 505.60).
TCO-PEG6-acid — Reference use: TCO PEG linker studies involving tetrazine ligation and carboxyl-group coupling.
For TCO-PEG6-acid, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- AxisPharm AP10813
Useful catalog search terms
- CAS 2353409-97-7
- C24H43NO10
Physicochemical data
| Functional groups | TCO and carboxylic acid |
|---|---|
| PubChem CID | 146026006 |
| InChIKey | ACASMHHVQBAVOG-UPHRSURJSA-N |
| InChI | InChI=1S/C24H43NO10/c26-23(27)8-10-29-12-14-31-16-18-33-20-21-34-19-17-32-15-13-30-11-9-25-24(28)35-22-6-4-2-1-3-5-7-22/h1-2,22H,3-21H2,(H,25,28)(H,26,27)/b2-1- |
| SMILES | C1C/C=C\CCC(C1)OC(=O)NCCOCCOCCOCCOCCOCCOCCC(=O)O |
| Canonical SMILES | C1C/C=C\CCC(C1)OC(=O)NCCOCCOCCOCCOCCOCCOCCC(=O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe TCO-PEG6-acid or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.