Halogenated Nucleosides
2',5'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine
Quick view. Halogenated and protected guanosine derivative bearing 3'-fluoro substitution, 8-benzyloxy substitution, and acetyl esters at 2'-O and 5'-O. CAS 2389988-77-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',5'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine is classified as halogenated nucleosides (Formula C21H22FN5O7; molecular weight 475.43 g/mol).
2',5'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2',5'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2389988-77-4
Physicochemical data
| Nucleoside | 8-Benzyloxy-3'-deoxy-3'-fluoroguanosine |
|---|---|
| Protecting groups | 2'-O-acetyl and 5'-O-acetyl |
| Substitution pattern | 8-benzyloxy and 3'-fluoro |
| Stereochemical scope | Stereodefined beta-D nucleoside configuration |
| InChIKey | ADTXBERYSVSIRQ-NPNMTCQASA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',5'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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