Modified Nucleosides
2,4-Dithiopseudouridine
Quick view. An unprotected pseudouridine C-nucleoside bearing sulfur at both the 2 and 4 positions of the pyrimidine ring, CAS 2953069-13-9. CAS 2953069-13-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2,4-Dithiopseudouridine is classified as modified nucleosides (Formula C9H12N2O4S2; molecular weight 276.34).
2,4-Dithiopseudouridine is relevant to modified RNA, mRNA optimization, epitranscriptomic standards or immune-recognition studies depending on the format supplied.
For 2,4-Dithiopseudouridine, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- Amadis A1257130
Useful catalog search terms
- CAS 2953069-13-9
- C9H12N2O4S2
- 2,4-dithio pseudouridine
- A1257130
- FLENAHLGJXQQPY-GBNDHIKLSA-N
Physicochemical data
| Nucleoside | Pseudouridine C-glycoside |
|---|---|
| Base modification | 2,4-Dithio substitution |
| Hydroxyl pattern | Free 2', 3', and 5' hydroxyls |
| Stereochemistry | Four defined ribofuranosyl stereocenters |
| InChIKey | FLENAHLGJXQQPY-GBNDHIKLSA-N |
| SMILES | OC[C@H]1O[C@@H](c2c[nH]c(=S)[nH]c2=S)[C@H](O)[C@@H]1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe 2,4-Dithiopseudouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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