Modified Nucleosides
2'-O-Propargyladenosine
Quick view. A 2'-O-propargyl adenosine building block for modified-nucleoside and nucleic-acid chemistry research. CAS 151390-97-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Propargyladenosine is classified as modified nucleosides (Formula C13H15N5O4; molecular weight 305.29).
2'-O-Propargyladenosine — 2'-O-propargyl adenosine building block for structure-specific modified-nucleoside and nucleic-acid chemistry research.
For 2'-O-Propargyladenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 2'-O-(2-Propyn-1-yl)adenosine
- 2'-O-propargyl-rA
- 2'-O-propynyl-adenosine
- 2'-O-Propargyl-D-adenosine
- TNU0205
- NP00748
Useful catalog search terms
- CAS 151390-97-5
Physicochemical data
| InChIKey | ROHGEAZREAFNTO-QYVSTXNMSA-N |
|---|---|
| SMILES | C#CCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N)ncnc21 |
| Sugar modification | 2'-O-propargyl |
| Chemical form | Unprotected adenosine nucleoside |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 2'-O-Propargyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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