Halogenated Nucleosides
3'-Deoxy-3'-fluoro-5-fluorouridine
Quick view. 3'-Deoxy-3'-fluoro-5-fluorouridine is a dual-fluorinated uridine nucleoside with CAS 112668-56-1. CAS 112668-56-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-Deoxy-3'-fluoro-5-fluorouridine is classified as dual-fluorinated uridine nucleoside (Formula C9H10F2N2O5; molecular weight 264.18).
3'-Deoxy-3'-fluoro-5-fluorouridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3'-Deoxy-3'-fluoro-5-fluorouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-Deoxy-3',5-difluorouridine
- PubChem CID 14071470
Useful catalog search terms
- CAS 112668-56-1
- 3'-deoxy-3'-fluoro-5-fluoro-uridine
Physicochemical data
| IUPAC name | 5-fluoro-1-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
|---|---|
| InChI | InChI=1S/C9H10F2N2O5/c10-3-1-13(9(17)12-7(3)16)8-6(15)5(11)4(2-14)18-8/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5-,6-,8-/m1/s1 |
| InChIKey | GJXRADCYCFGMRR-UAKXSSHOSA-N |
| SMILES | C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)F)O)F |
| Structural feature | 3'-fluoro sugar and 5-fluoro uracil |
| PubChem CID | 14071470 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-Deoxy-3'-fluoro-5-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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