Halogenated Nucleosides
3'-Deoxy-3'-fluoro-xyloadenosine
Quick view. Xyloadenosine derivative in which fluorine replaces the sugar 3'-hydroxyl, with free 2'- and 5'-hydroxyl groups. CAS 20535-16-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-Deoxy-3'-fluoro-xyloadenosine is classified as halogenated nucleosides (Formula C10H12FN5O3; molecular weight 269.24 g/mol).
3'-Deoxy-3'-fluoro-xyloadenosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3'-Deoxy-3'-fluoro-xyloadenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 9-(3'-Fluoro-3'-deoxyxylofuranosyl)adenine
- (2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol
Useful catalog search terms
- 20535-16-4
Physicochemical data
| Sugar modification | 3'-deoxy-3'-fluoro beta-D-xylofuranose |
|---|---|
| Hydroxyl state | 2' and 5' hydroxyl groups unprotected |
| InChIKey | QCDAWXDDXYQEJJ-GQTRHBFLSA-N |
| InChI | InChI=1S/C10H12FN5O3/c11-5-4(1-17)19-10(7(5)18)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5+,7-,10-/m1/s1 |
| SMILES | C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@H]([C@H](O3)CO)F)O)N |
| PubChem CID | 11821635 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-Deoxy-3'-fluoro-xyloadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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