Modified Nucleosides
3'-O-(2-Methoxyethyl)-5-methyluridine
Quick view. A 5-methyluridine nucleoside bearing a 3'-O-(2-methoxyethyl) substituent. CAS 303197-29-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-(2-Methoxyethyl)-5-methyluridine is classified as 3'-o-substituted 5-methyluridine nucleoside (Formula C13H20N2O7; molecular weight 316.31 g/mol).
3'-O-(2-Methoxyethyl)-5-methyluridine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-(2-Methoxyethyl)-5-methyluridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Useful catalog search terms
- 303197-29-7
- JFKOVKUSGMUXKQ-DNRKLUKYSA-N
Physicochemical data
| PubChem CID | 18719642 |
|---|---|
| IUPAC name | 1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| InChIKey | JFKOVKUSGMUXKQ-DNRKLUKYSA-N |
| InChI | InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-9(17)10(8(6-16)22-12)21-4-3-20-2/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)OCCOC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(2-Methoxyethyl)-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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