Modified Nucleosides
4',5'-Didehydro-2',5'-dideoxyuridine
Quick view. A uridine analogue with a 4',5'-unsaturated sugar and 2',5'-dideoxy substitution pattern while retaining the uracil base. CAS 58096-66-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
4',5'-Didehydro-2',5'-dideoxyuridine is classified as unsaturated dideoxy uridine nucleoside (Formula C9H10N2O4; molecular weight 210.19 g/mol).
4',5'-Didehydro-2',5'-dideoxyuridine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 4',5'-Didehydro-2',5'-dideoxyuridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Uridine, 4',5'-didehydro-2',5'-dideoxy-
- 1-[(2R,4S)-4-Hydroxy-5-methylideneoxolan-2-yl]pyrimidine-2,4(1H,3H)-dione
Useful catalog search terms
- 58096-66-5
- GWUGJFCGJLMLER-POYBYMJQSA-N
Physicochemical data
| InChIKey | GWUGJFCGJLMLER-POYBYMJQSA-N |
|---|---|
| InChI | InChI=1S/C9H10N2O4/c1-5-6(12)4-8(15-5)11-3-2-7(13)10-9(11)14/h2-3,6,8,12H,1,4H2,(H,10,13,14)/t6-,8+/m0/s1 |
| SMILES | C=C1[C@H](C[C@@H](O1)N2C=CC(=O)NC2=O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 4',5'-Didehydro-2',5'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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