2'-O-MOE Nucleosides
5'-Deoxy-5'-iodo-2'-O-(2-methoxyethyl)-5-methyluridine
Quick view. 5-Methyluridine derivative bearing 5'-deoxy-5'-iodo and 2'-O-(2-methoxyethyl) sugar modifications. CAS 2095417-53-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Deoxy-5'-iodo-2'-O-(2-methoxyethyl)-5-methyluridine is classified as 2'-o-moe nucleosides (Formula C13H19IN2O6; molecular weight 426.21 g/mol).
5'-Deoxy-5'-iodo-2'-O-(2-methoxyethyl)-5-methyluridine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-Deoxy-5'-iodo-2'-O-(2-methoxyethyl)-5-methyluridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Useful catalog search terms
- 2095417-53-9
Physicochemical data
| Base scaffold | 5-methyluridine |
|---|---|
| Sugar modification | 2'-O-(2-methoxyethyl) |
| 5' modification | 5'-deoxy-5'-iodo |
| InChIKey | MJUUXYHNHGVDHQ-DNRKLUKYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-Deoxy-5'-iodo-2'-O-(2-methoxyethyl)-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.