Halogenated Nucleosides
5-Iodo-2',3'-dideoxyuridine
Quick view. 5-Iodo-2',3'-dideoxyuridine is a 5-iodinated dideoxyuridine derivative with CAS 105784-83-6. CAS 105784-83-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Iodo-2',3'-dideoxyuridine is classified as halogenated dideoxynucleoside (Formula C9H11IN2O4; molecular weight 338.10 (calculated from molecular formula)).
5-Iodo-2',3'-dideoxyuridine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 5-Iodo-2',3'-dideoxyuridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Uridine, 2',3'-dideoxy-5-iodo-
Useful catalog search terms
- CAS 105784-83-6
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H11IN2O4/c10-6-3-12(9(15)11-8(6)14)7-2-1-5(4-13)16-7/h3,5,7,13H,1-2,4H2,(H,11,14,15)/t5-,7+/m0/s1 |
|---|---|
| InChIKey | OBGFSDPYSQAECJ-CAHLUQPWSA-N |
| SMILES | C1C[C@@H](O[C@@H]1CO)N2C=C(C(=O)NC2=O)I |
| Structural features | 2',3'-Dideoxyuridine bearing iodine at the 5-position |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5-Iodo-2',3'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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