dNTPs
5-Propargylamino-dCTP
Quick view. A C5-propargylamino-modified dCTP for modified-nucleotide incorporation and two-step DNA labeling research. CAS 115899-39-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Propargylamino-dCTP is classified as dntps.
5-Propargylamino-dCTP — Modified dCTP incorporation research
For 5-Propargylamino-dCTP, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 5-Propargylamino-2'-deoxycytidine-5'-triphosphate
- Propargylamino-dCTP
- PA-dCTP
Useful catalog search terms
- 115899-39-3
Physicochemical data
| Parent InChIKey | LVTQIVFSMGDIPF-IVZWLZJFSA-N |
|---|---|
| Modification | C5 propargylamino handle on dCTP |
| Supply Form | Sodium-salt solid or aqueous solution; confirm counterion stoichiometry for requested material |
| Solid Form | White to off-white solid |
| Solution Form | Slightly yellow aqueous solution |
| Solution concentration | 100-110 mM; pH 7.5 +/-0.5 |
| Storage temperature | -20 C |
| PubChem CID | 11283796 |
| InChIKey | LVTQIVFSMGDIPF-IVZWLZJFSA-N |
| InChI | InChI=1S/C12H19N4O13P3/c13-3-1-2-7-5-16(12(18)15-11(7)14)10-4-8(17)9(27-10)6-26-31(22,23)29-32(24,25)28-30(19,20)21/h5,8-10,17H,3-4,6,13H2,(H,22,23)(H,24,25)(H2,14,15,18)(H2,19,20,21)/t8-,9+,10+/m0/s1 |
| SMILES | NCC#Cc1cn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)nc1N |
| Free-acid molecular formula | C12H19N4O13P3 |
| Formula basis | Free-acid form |
| Free-acid molecular weight | 520.22 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Two-step DNA labeling and amine-conjugation workflow development
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5-Propargylamino-dCTP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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