Linker Phosphoramidites
5'-Thiol-Modifier C6
Quick view. 5'-Thiol-Modifier C6 is an S-trityl-protected C6 thiol phosphoramidite identified by CAS 116919-17-6 for oligonucleotide synthesis research. CAS 116919-17-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Thiol-Modifier C6 is classified as linker phosphoramidites (Formula C34H45N2O2PS; molecular weight 576.78).
5'-Thiol-Modifier C6 — Reference use: introduction of a protected C6 thiol functionality at the 5' terminus during oligonucleotide synthesis.
For 5'-Thiol-Modifier C6, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5'-Thiol-Modifier C6 CE-Phosphoramidite
- Trityl-6-Thiohexyl Amidite
- 2-cyanoethyl (6-(tritylthio)hexyl) diisopropylphosphoramidite
Useful catalog search terms
- CAS 116919-17-6
- C34H45N2O2PS
Physicochemical data
| Systematic-name reference | 2-cyanoethyl (6-(tritylthio)hexyl) diisopropylphosphoramidite |
|---|---|
| Product-form boundary | Distinct from Thiol-Modifier C6 S-S (CAS 148254-21-1) |
| InChIKey | GLSHNXWOHYCVKS-UHFFFAOYSA-N |
| InChI | InChI=1S/C34H45N2O2PS/c1-29(2)36(30(3)4)39(38-27-18-25-35)37-26-16-5-6-17-28-40-34(31-19-10-7-11-20-31,32-21-12-8-13-22-32)33-23-14-9-15-24-33/h7-15,19-24,29-30H,5-6,16-18,26-28H2,1-4H3 |
| SMILES | CC(C)N(C(C)C)P(OCCCCCCSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)OCCC#N |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCCCCCSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)OCCC#N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5'-Thiol-Modifier C6 or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Linker Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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