dNTPs
7-Deaza-7-propargylamino-dATP
Quick view. A propargylamino-modified deoxyadenosine triphosphate for gene-sequencing and nucleic-acid functionalization research. CAS 587848-72-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
7-Deaza-7-propargylamino-dATP is classified as dntps (Formula C14H20N5O12P3; molecular weight 543.26).
7-Deaza-7-propargylamino-dATP — Modified-dATP reagent for gene-sequencing research
For 7-Deaza-7-propargylamino-dATP, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Useful catalog search terms
- 587848-72-4
Physicochemical data
| Nucleotide type | Modified deoxyadenosine triphosphate |
|---|---|
| Functional handle | Propargylamine |
| Reference Storage Conditions | 2-8 C sealed and dry, or -20 C for reviewed powder formats; follow supplied product documentation |
| PubChem CID | 101377226 |
| InChIKey | PCAJRNFTCPOUJA-HBNTYKKESA-N |
| InChI | InChI=1S/C14H20N5O12P3/c15-3-1-2-8-5-19(14-12(8)13(16)17-7-18-14)11-4-9(20)10(29-11)6-28-33(24,25)31-34(26,27)30-32(21,22)23/h5,7,9-11,20H,3-4,6,15H2,(H,24,25)(H,26,27)(H2,16,17,18)(H2,21,22,23)/t9-,10+,11+/m0/s1 |
| SMILES | NCC#Cc1cn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c2ncnc(N)c12 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Propargylamine-handle functionalization before or after enzymatic DNA synthesis
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 7-Deaza-7-propargylamino-dATP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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