ddNTPs
7-Deaza-7-propargylamino-ddATP
Quick view. A propargylamino-modified dideoxyadenosine triphosphate for gene-sequencing research. CAS 114748-69-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
7-Deaza-7-propargylamino-ddATP is classified as ddntps (Formula C14H20N5O11P3; molecular weight 527.26).
7-Deaza-7-propargylamino-ddATP — Modified-ddATP reagent for gene-sequencing research
For 7-Deaza-7-propargylamino-ddATP, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Useful catalog search terms
- 114748-69-5
Physicochemical data
| Nucleotide type | Modified 2',3'-dideoxyadenosine triphosphate |
|---|---|
| Functional handle | Propargylamine |
| Storage temperature | -20 C for powder format |
| PubChem CID | 11249496 |
| InChIKey | LQOGZFINDBWPBN-WDEREUQCSA-N |
| InChI | InChI=1S/C14H20N5O11P3/c15-5-1-2-9-6-19(14-12(9)13(16)17-8-18-14)11-4-3-10(28-11)7-27-32(23,24)30-33(25,26)29-31(20,21)22/h6,8,10-11H,3-5,7,15H2,(H,23,24)(H,25,26)(H2,16,17,18)(H2,20,21,22)/t10-,11+/m0/s1 |
| SMILES | NCC#Cc1cn([C@H]2CC[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c2ncnc(N)c12 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 7-Deaza-7-propargylamino-ddATP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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