Halogenated Nucleosides
8-Benzyloxy-3'-deoxy-3'-fluoroguanosine
Quick view. Halogenated guanosine derivative bearing an 8-benzyloxy substituent and fluorine at the 3' position. CAS 2389988-61-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
8-Benzyloxy-3'-deoxy-3'-fluoroguanosine is classified as halogenated nucleosides (Formula C17H18FN5O5; molecular weight 391.40 g/mol).
8-Benzyloxy-3'-deoxy-3'-fluoroguanosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 8-Benzyloxy-3'-deoxy-3'-fluoroguanosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2389988-61-6
Physicochemical data
| PubChem CID | 153283062 |
|---|---|
| IUPAC name | 2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-phenylmethoxy-1H-purin-6-one |
| Nucleoside | Guanosine |
| Substitution pattern | 8-benzyloxy and 3'-deoxy-3'-fluoro |
| Free hydroxyl groups | 2' and 5' |
| Stereochemical scope | (2R,3S,4S,5R) oxolane configuration |
| InChIKey | SHIMOFPIGKCDPN-NDLNZWKESA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 8-Benzyloxy-3'-deoxy-3'-fluoroguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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