Modified Nucleosides
8-Mercaptoguanosine
Quick view. A guanosine nucleoside bearing a mercapto/thioxo modification at purine C8, identified by CAS 26001-38-7. CAS 26001-38-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
8-Mercaptoguanosine is classified as modified nucleosides (Formula C10H13N5O5S; molecular weight 315.31).
8-Mercaptoguanosine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 8-Mercaptoguanosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 8-Thioguanosine
- 8-SH-Guo
- 8-Mercapto-D-guanosine
- 7,8-Dihydro-8-thioxoguanosine
- Guanosine, 7,8-dihydro-8-thioxo-
Useful catalog search terms
- CAS 26001-38-7
- Alternate CAS 29836-03-1
- PubChem CID 135457302
Physicochemical data
| PubChem CID | 135457302 |
|---|---|
| InChIKey | KZELNMSPWPFAEB-UMMCILCDSA-N |
| Nucleoside | guanosine |
| Modification | purine C8 mercapto/thioxo |
| Alternate registry identifier | 29836-03-1 |
| InChI | InChI=1S/C10H13N5O5S/c11-9-13-6-3(7(19)14-9)12-10(21)15(6)8-5(18)4(17)2(1-16)20-8/h2,4-5,8,16-18H,1H2,(H,12,21)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1 |
| SMILES | C([C@@H]1[C@H]([C@H]([C@@H](O1)N2C3=C(C(=O)NC(=N3)N)NC2=S)O)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 8-Mercaptoguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.