Other Phosphoramidites
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite
Quick view. A protected cytidine phosphoramidite with geminal 2',2'-difluoro substitution, 5-O-DMTr protection and an N4-benzoyl-protected cytosine base. CAS 142808-44-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite is classified as protected geminal-difluoro cytidine phosphoramidite (Formula C46H50F2N5O8P; molecular weight 869.89).
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2',2'-difluoro-dC(Bz)-3'-CED-phosphoramidite
- Gemcitabine 3'-CE phosphoramidite
Useful catalog search terms
- 142808-44-4
Physicochemical data
| Nucleoside modification | 2',2'-Difluoro-2'-deoxycytidine |
|---|---|
| Protecting groups | 5-O-DMTr; N4-benzoyl |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.