LNA Phosphoramidites
DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite is the 5'-O-DMTr, N2-dimethylformamidine-protected LNA-guanosine 3'-cyanoethyl phosphoramidite identified by CAS 709641-79-2. CAS 709641-79-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite is classified as lna phosphoramidites (Formula C44H53N8O8P; molecular weight 852.93).
DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite is useful for high-affinity probes, SNP/mismatch-discrimination studies, antisense designs and short sequence probes.
For DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- LNA-G(dmf)-Phosphoramidite
- LNA-G(dmf)-CE Phosphoramidite
- 5'-DMTr-LNA-G(N-dmf) Phosphoramidite
Useful catalog search terms
- 709641-79-2
- ACJXYPZQPQPGNE-UHVFFKTASA-N
Physicochemical data
| Systematic name | (E)-N'-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide |
|---|---|
| InChIKey | ACJXYPZQPQPGNE-UHVFFKTASA-N |
| Chemical form | 5'-O-DMTr, N2-dimethylformamidine LNA-guanosine 3'-cyanoethyl phosphoramidite |
| InChI | InChI=1S/C44H53N8O8P/c1-29(2)52(30(3)4)61(58-24-12-23-45)60-38-37-41(51-28-46-36-39(51)48-42(49-40(36)53)47-27-50(5)6)59-43(38,25-56-37)26-57-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,37-38,41H,12,24-26H2,1-8H3,(H,48,49,53)/b47-27+/t37-,38+,41-,43-,61?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H]2[C@@H](O[C@]1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)/N=C/N(C)C |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H]2[C@@H](O[C@]1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)/N=C/N(C)C |
| PubChem CID | 156688488 |
| Structure representation | Complete LNA-G(dmf) protected form with four assigned LNA centres, E dimethylformamidine and phosphorus configuration left unspecified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
DMTr-2'-O-4'-C-Locked-rC(Ac)-3'-CE-Phosphoramidite
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OR-LP-0002DMTr-2'-O-4'-C-Locked-5-Me-rC(Ac)-3'-CE-Phosphoramidite
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OR-LP-0003DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-82-5
OR-LP-0004DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-79-0
OR-LP-0005DMTr-2'-O-4'-C-Locked-rC(Bz)-3'-CE-Phosphoramidite
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OR-LP-0007DMTr-2'-O-4'-C-Locked-rG(iBu)-3'-CE-Phosphoramidite
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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