Other Phosphoramidites
5'-O-DMTr-2'-Trifluoroacetamido-C(Ac)-3'-CE-Phosphoramidite
Quick view. An N4-acetyl-protected 2'-amino-2'-deoxycytidine 3'-CE phosphoramidite bearing 5'-O-DMTr and N-trifluoroacetyl protection. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-2'-Trifluoroacetamido-C(Ac)-3'-CE-Phosphoramidite is classified as protected 2'-amino-2'-deoxycytidine phosphoramidite (Formula C43H50F3N6O9P; molecular weight 882.88).
5'-O-DMTr-2'-Trifluoroacetamido-C(Ac)-3'-CE-Phosphoramidite is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5'-O-DMTr-2'-Trifluoroacetamido-C(Ac)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- DMTr-2'-Trifluoroacetamido-rC(Ac)-3'-CE-Phosphoramidite
Useful catalog search terms
- 2'-amino cytidine phosphoramidite
Physicochemical data
| Base protection | N4-acetyl |
|---|---|
| Amino protection | N-trifluoroacetyl |
| 5' protection | DMTr |
| Phosphoramidite group | 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-Trifluoroacetamido-C(Ac)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.